Much of weight gain on medications is subject to genetics. Take two people with identically healthy lifestyles and put them on the same dosage of Gabapentin for the same duration. One of those individuals may end up gaining 10 lbs., while the other may lose 5 lbs. What would explain the difference between these two individuals? Genetics as well as epigenetics or gene expression in response to the environment.

The use of parenteral phenytoin is complicated by poor solubility, high alkalinity, hypotension, cardiac arrhythmias and the potential for soft tissue injury with extravasation. However, fosphenytoin can be administered intravenously or intramuscularly with a low risk of tissue irritation. No significant electrocardiographic changes have been noted with either intravenous or intramuscular administration. Mild decrements in mean systolic blood pressure have been reported with intravenous administration.

The medication may come with general side effects such as headaches, insomnia, nausea, changes in sexual behavior. These symptoms are only common for first few weeks and the body tends to adjusts to the drug. The drug is not recommended to pregnant women. The effectiveness of SSRIs in pediatric cases of depression has been found positive. b) Anti anxiety agents: Ativan and Klonopin are the most suggested Anti anxiety agents. These are also known to initiate anxiety management. The researches have found positive results with the use of these two anti-anxiety agents. More common side effects may include: dizziness; drowsiness; swelling of your ankles, feet, or hands.

Court documents revealed that senior officials at Parke-Davis determined that it was not sufficiently profitable for Parke-Davis to obtain FDA approval for gabapentin’s alternative uses mentioned above by doing the types of studies necessary for approval. Instead, company officials developed a strategy that would allow Parke-Davis to avoid the costs of proving gabapentin 800 mg drug‘s safety and effectiveness for these other uses, while allowing the company to enter the lucrative off-label markets.

I started taking gabapentin a few weeks ago at 900mg a day and the drug alleviated symptoms of my depression, anxiety, irritability, and I was able to sleep well again. The side effects of the medication even subsided over time. I notice now that some of my symptoms are coming creeping back to the point where my daily dosage of gabapentin will have to be increased gradually. Does this drug lose its effectiveness over time such that its dosage needs to be adjusted regularly? Thank you.